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Cantilever DNA Sensors

Application Notes and Data Obtained with Cantisens Research

  DNA Hybridization: Detection of Specific DNA Sequences

Functionalised with single-stranded DNA, cantilevers can be used to specifically and sensitively detect DNA sequences. The example shows the specific detection of two sequences, which are specific for two HIV strains (NL4-3, SF162; 77% homologous). At the timepoints indicated different DNAs were injected, and the cantilever deflections (HIV-sequence minus reference channel) were monitored over time.

The red curve shows the reaction of the HIV NL4-3 specific cantilever, the blue line the deflection of the HIV SF162 specific cantilever.

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